To assess if the phenotype and functional status of macrophages (differentiated in the absence of IL17A) paralleled a different tumor microenvironment (TME) in vivo, we took advantage of having FFPE pancreatic tumors excised from WT mice orthotopically injected with PDAC cells, and untreated or treated with the anti-IL17A mAb. This evidence concerns the gene IL17A and pancreatic neoplasm.