PDGFB and central nervous system cancer: Moreover, PDGFB-induced glioma primary cells (PIGPC) derived from RCAS-PDGFB-induced gliomas in Nestin-tv-a Ink4a/Arf-/- mice showed increased colony numbers, as well as visibly larger colonies when cultured on ADM1 compared to colonies formed on ADM21 (Figure 4C).