Polyamines also activate oncogenic signaling, as depletion of spermidine/spermine N1-acetyltransferase (SSAT) in CRC cells resulted in increased level of spermidine and spermine and the expression of pAKT and β-catenin and promoted cell proliferation and tumor metastasis [96]. This evidence concerns the gene SAT1 and colorectal carcinoma.