Consistent with above, sulforaphane, a potent histone deacetylase inhibitor, that also down-regulated DNMTs, drove CpG demethylation and hyperacetylation of the regulatory region (from UTSS, −202 to +106) of TERT and promoted binding of MAD1 and CTCF to the TERT promoter in MCF-7 and MDA-MB-231 human breast cancer cells [132]. This evidence concerns the gene TERT and breast carcinoma.