In advanced lung cancer patients with systemic immune metabolic syndrome (SIMS, defined by presence of cachexia, anorexia, ECOG (Eastern Cooperative Oncology Group) status > 2 and high CRP), the combination of 600 mg EPA + DHA and celecoxib (non-steroidal anti-inflammatory drug) increased body weight by approximately 1.2 kg compared to the n-3 capsules alone over a 6-week intervention [52]. This evidence concerns the gene CRP and Cachexia.