Thus, combination with other specific surface markers such as CD25, CD26, CD33, CD56, CD36, CD123 (the α chain of the IL-3 receptor), IL-1RAP (interleukin-1 receptor accessory protein) has been proposed to specifically identify LSCs population among all CML cells [14,16]. This evidence concerns the gene IL1RAP and chronic myelogenous leukemia, BCR-ABL1 positive.