Similarly, clinical reports suggest that initial high numbers of Tregs prevent successful therapeutic outcome of allogeneic stem cell transplantation (SCT) in CML [181] and that depletion of CD4+ CD25+ cells from donor infusions may potentially improve efficacy of SCT without induction of graft-versus-host disease [182]. This evidence concerns the gene CD4 and chronic myelogenous leukemia, BCR-ABL1 positive.