Immunophenotyping studies have evaluated functional phenotype of these cells, and peripheral blood (PB) CD8+ T cells at diagnosis in AML patients had an antigen-experienced, terminally differentiated phenotype and expressed markers connected with T cell exhaustion, such as programmed cell death protein 1 (PD-1), 2B4, lymphocyte-activation gene 3 (LAG-3), TIGIT (T cell immunoglobulin and ITIM domain), and senescence marker CD57. This evidence concerns the gene LAG3 and acute myeloid leukemia.