EVs derived from K562 CML cells influenced phenotype of macrophages, by inducing secretion of interleukin 10 (IL-10) and TNF-α and decreasing release of NO (nitric oxide) and expression of inducible nitric oxide synthase (iNOS), suggesting possible polarization towards an immunosuppressive phenotype [147]. This evidence concerns the gene NOS2 and chronic myelogenous leukemia, BCR-ABL1 positive.