High Neo-fs index samples were enriched for genes linked to immune activation-associated signatures (e.g., plasmacytoid dendritic cells, cytolytic activity, MHC class I, and CD8+ T cell) had a reduced the gene signatures related to immune suppression such as type II-IFN response, which might have affected the response to AAA as well as favorable survival in general. This evidence concerns the gene CD8A and triple-A syndrome.