EGF and squamous cell carcinoma: Similar to Oldrini et al. who reported that RCN1 binds EGF-stimulated wt EGFR in the epidermoid carcinoma cell line A431 [48], we found that RCN1 could associate with the wt EGFR in both U87vIII and U373vIII cells despite these cell lines expressing greater levels of EGFRvIII than wt EGFR.