HSPA5 and nasopharyngeal carcinoma: Similar to our findings, Huang et al., showed that knockdown of RCN1 enhanced the expression of ER stress markers GRP78, CHOP, Herp, Erdj4, ATF4 and EDEM1 and promoted apoptosis in nasopharyngeal carcinoma cells when challenged with the chemotherapeutic adriamycin [40].