Similar to Oldrini et al. who reported that RCN1 binds EGF-stimulated wt EGFR in the epidermoid carcinoma cell line A431 [48], we found that RCN1 could associate with the wt EGFR in both U87vIII and U373vIII cells despite these cell lines expressing greater levels of EGFRvIII than wt EGFR. This evidence concerns the gene EGFR and squamous cell carcinoma.