CD8A and infection: By using T lymphocytes specific GPX4 knockout mice as a model, it was reported that GPX4 is vital for the homeostatic survival of CD8+ T cells in the periphery (spleen, peripheral lymph node and mesenteric lymph node), as well as for the expansion of both CD4+ and CD8+ T cells upon T cell receptor triggering in response to infection through preventing lipid peroxidation and counteracting ferroptosis [26].