TP53 and lung adenocarcinoma: Moreover, β-elemene was also found to reverse drug resistance through the mitochondrial apoptosis pathway in the cisplatin-resistant human lung adenocarcinoma A549/DDP cells and through inducing pro-death autophagy and arresting the cell cycle dependent on cyclin D3 in the 5-fluorouracil resistant human p53-deficient colorectal cancer lines HCT116p53-/- [62,63].