Subsequent investigations demonstrated that β-elemene increased insulin-like growth factor-binding proteins 1 (IGFBP 1) gene expression through inactivating Stat3 as well as the interaction between miRNA155-5p and human forkhead box class O 3a (FoxO 3a), leading to the inhibition of human lung cancer A549 and H1975 cell growth [23]. The gene discussed is IGFBP1; the disease is lung cancer.