AKT1 and glioblastoma: β-Elemene was found to improve the radiosensitivity (X-ray, 3.38 Gray/min, 2/4/6/10 Gray) and chemosensitivity (temozolomide) of the human glioblastoma multiforme (GBM) cell lines (U87MG, T98, U251, and LN229) associated with the inhibition of DNA damage repair through ATM, AKT, and ERK signaling pathways [64].