Decreased production of NF-κB and COX-2 gene and protein levels may be responsible for decreased pro-inflammatory cytokine production by macrophages.n-3 PUFA exhibit anti-inflammatory properties in many inflammatory diseases including IBD, psoriasis, rheumatoid arthritis, chronic hepatitis etc. Omega-3 FAs reduce acute and chronic inflammatory reaction through various pathways. Here, NFKB1 is linked to inflammatory bowel disease.