Three patients with serum morning cortisol <3 or ≥18 μ/dL, 2 patients with incomplete results from the ACTH stimulation tests, 1 patient who was on oral contraceptive pills, 2 patients who had pituitary surgery in the past 2 months, 2 patients with congenital adrenal hyperplasia, and 10 patients with primary AI were excluded. Here, POMC is linked to congenital adrenal hyperplasia.