Some protocols propose that if serum cortisol is drawn at 08:00 and the level is below 3–5 μg/dL (83–138 nmol/L), it is strongly suggestive of AI and indicates that other dynamic tests, e.g., an ACTH stimulation test or insulin-induced hypoglycemia, are not necessary [8,9]. Here, POMC is linked to Hypoglycemia.