SLC26A4 and atrial fibrillation: In addition to being classified as a pathogenic variant by many predictive algorithms (SIFT, DANN, EIGEN, FATHMM-MKL, MutationTaster, and others) and databases that include ClinVar, DVD, and Uniprot, p.C565Y also demonstrated low allelic frequency (AF) across populations (Popmax Filtering AF < 0.0001 in GenomAD) and location at a critical domain of pendrin where pathogenic SLC26A4 variants were recurrently detected.