These findings are consistent with studies that identified FLT4 hypermethylation as one of the markers for early/late-stage oral squamous cell carcinoma [36] and cg00489401 (FLT4) as one of the differentiating markers between localized and advanced-stage type 2 Papillary Renal Cell Carcinoma [37]. This evidence concerns the gene FLT4 and oral cavity squamous cell carcinoma.