We identified overexpression of ERN2 and other kinases including NIMA-related kinase 2 (NEK2), serine/threonine/tyrosine kinase 1 (STYK1), and polo-like kinase 1 (PLK1) in a subset of 146 pancreatic ductal adenocarcinoma (PDAC) patients after removing endocrine, invasive adenocarcinoma, undifferentiated, or mixed pancreatic cancers from TCGA-PAAD samples [57]. This evidence concerns the gene PLK1 and pancreatic ductal adenocarcinoma.