Distance mapping–based Meta-MSEA (Figure S3) showed 8 (3%) pathways shared by IGF-I and IR, including known IGF/IR axis pathways (e.g., gene control of body mass index and lipid metabolism) as well as lesser-known pathways, including mucopolysaccharidosis type III, Notch-1 heterodimerization domain mutation in cancer, and serotonin neurotransmitter release cycle. The gene discussed is NOTCH1; the disease is cancer.