For shared pathways across the phenotypes and IR-specific pathways, we detected repeated but meaningful PPI-specific subnetworks, such as T2DM, adipokin, insulin, and EGFR signaling and, additionally, their neighboring subnetworks, including MAPK, innate immune system, ERBB4, and renal-cell carcinogenetic mechanism. The gene discussed is EGFR; the disease is type 2 diabetes mellitus.