Some of the top pathways were similar to those from IGF-I-specific pathways, such as T2DM, corticosteroid mechanism, mechanisms of lipids and lipoproteins, fatty acid, and triglycerides (TG), and EGFR signaling, whereas IR-unique pathways included mechanistic target of rapamycin (mTOR) signaling, phosphoinositide 3-kinase (PI3K) subunit p85, and erb-b2 receptor tyrosine kinase 4 (ERBB4) signaling. This evidence concerns the gene ERBB4 and type 2 diabetes mellitus.