INSR and type 2 diabetes mellitus: Those shared pathways included cellular-based pathways, such as heparan sulfate/heparin biosynthesis and mitochondrial protein import, and well-known IGF-I/IR axis pathways, including T2DM, lipoprotein metabolism, and EGFR signaling (Figure S4) As described, the Meta-MSEA analysis of eQTL-based mapping pathways for IGF-I and IR, compared with the analysis of the distance-based mapping pathways, yielded more informative pathways.