Notably, in one study on advanced melanoma, TIGIT was upregulated and coexpressed with PD-1 in the majority of CD8+ TILs, and a dual blockade with TIGIT and PD-1 blockade additively increased proliferation, cytokine production, and degranulation in tumor antigen-specific CD8+ T cells [44]. The gene discussed is TIGIT; the disease is melanoma.