Furthermore, PrVI UTRs showed high nucleotide similarities with those of their cognate ilarviruses from subgroup I. A series of studies have shown that alfalfa mosaic virus (AMV) and ilarviruses require the interaction of their own CP with the 3′UTRs of their viral RNAs to initiate replication and establish infection [7,8] and this function was termed “genome activation” [9]. This evidence concerns the gene CP and infection.