MAPT and Alzheimer disease: Although several CaM-dependent kinases and phosphatases are involved in tau posttranslational modification, for instance Ca2+/CaM-dependent protein kinase II (CaMKII), cyclin-dependent kinase 5 or protein phosphatase 2B (PP2B or calcineurin) [67], no recent studies have further expanded the functional significant of direct interaction with CaM and tau in the AD.