Chronic inflammation is an important oncogenic factor; for example, tumor-associated macrophages promote tumor cell hyperplasia via the secretion of growth factors, promote angiogenesis via the secretion of vascular endothelial growth factor (VEGF), promote metastasis and invasion tumors via secretion of matrix metalloproteinases, and also suppress adaptive immunity via secretion of various immunosuppressive cytokines [77,132,133,134,135,136]. Here, VEGFA is linked to neoplasm.