These researchers examined the canine counterparts of three human cancers: chronic myelogenous leukemia (CML) associated with BCR and ABL fusion, sporadic Burkitt lymphoma (BL) associated with MYC-IgH fusion, and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) associated with a hemizygous deletion harboring the RB1 gene. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.