FOS and breast cancer: Kaya et al. demonstrated that Curcumae Radix (CR) ethanol extract prolonged the median survival time of breast cancer model and inhibited lung metastasis, the most frequent aspect of breast cancer metastasis, through regulating the C-C chemokine receptor type 7 (CCR7)-AP-1(c-fos, c-jun)-MMP-9 pathway [117].