Syndecan-1 is known to establish interactions with high-affinity tyrosine kinase receptors; therefore, it looked conceivable that its accelerated shedding might influence kinase activity, and elevated shedding in hSDC1+/+ DEN may contribute to the removal of growth factors from the tumor cell surface and thereby attenuate the activation of cell surface receptors. The gene discussed is SDC1; the disease is neoplasm.