BRAF and neoplasm: Interestingly, the authors found remarkable clear proliferations of sub-clones with different BRAF status in the same sample of acral melanoma (intra-tumour heterogeneity), as well as detected different BRAF status comparing some metastatic lesions of acral melanoma with primary lesions (inter-tumour heterogeneity), highlighting that the exclusive inclusion of acral melanoma might have contributed to the high rate of heterogeneity reported [47].