Most common ≥ Gr 3 AEs: nausea, diarrhea, vomiting, neutropenia, lymphopenia, thrombocytopenia and anemia were observed. 40% of patients had serious AEs including colitis, diarrhea and hypotension. 1 patient had Gr 3 pneumonitis and none of patients showed PJP or Gr ≥ 2 ALT. This evidence concerns the gene GPT and pneumonitis.