In NHL patients, Gr 3 or higher AEs were diarrhea, fatigue, nausea, rash, pyrexia and chills. Other abnormalities included neutropenia, anemia, thrombocytopenia and elevation in serum transaminase level [332]. In CLL patients Gr 3 or higher AEs included pneumonia, neutropenic fever, colitis, cellulitis and diarrhea [333]. In MCL patients common AEs observed were diarrhea, nausea, pyrexia, fatigue, rash, decreased appetite, upper respiratory infection, pneumonia and ALT/AST increase [334]. This evidence concerns the gene GPT and B-cell chronic lymphocytic leukemia.