Single-cell suspensions of biopsy specimens from healthy and iNHL patients were incubated with or without Ide and stained with pAKT S473 and pS6 S235/6 antibodies. Both cells demonstrated complete or near-complete inhibition of p-AKT levels. PI3K distal downstream signaling (S6K) was completely inhibited by Ide in healthy B cells. The degree inhibition of S6K expression was variable between iNHL patients. Variable PI3K-independence was observed amongst other lymphomas such as MCL. This evidence concerns the gene PIK3CD and mantle cell lymphoma.