Most TEAEs were rash, colitis, diarrhea, nausea, cough and pyrexia. Other were Gr 3/4 AST and ALT elevations; Gr 3/4 neutropenia and anemia. The most frequent serious TEAEs were pyrexia, general physical health deterioration and hypercalcemia. The gene discussed is GPT; the disease is hypercalcemia disease.