DL 1: mucositis, fatigue, palmar-plantar erthrodyesthesia, rash, acneifrom, hypomagnesemia and increased AST/ALT.DL-1: rash, hypomagnesemia and increased AST.DL-1b: rash, mucositis, pruritus, dry skin, increase AST/ALT, hyperglycemia, nausea, anorexia and rash acneiform. The gene discussed is GPT; the disease is Hyperglycemia.