OGA and lung cancer: Our investigation of the regulation of O-GlcNAc-cycling enzymes in lung cancer cells in response to changes of O-GlcNAcylation status corroborated a general phenomenon observed in other cell types and systems [12,13,14,15,16,17,18]: cellular O-GlcNAcylation needs to be maintained at a homeostatic level, presumably to preserve proper cell functions, and this is achieved by compensatory modulation of the expression of OGT and OGA.