As Jian et al. showed an association between SOX11 and lymph node metastasis [25] and our results proved its association with the lymphovascular invasion rate, before the occurrence of metastasis, it is tempting to believe that SOX11 can be used for identification of those MMs with high risk of presence of circulating cells before clinical diagnosis of lymph node metastases. Here, SOX11 is linked to metastatic malignant neoplasm in the lymph nodes.