Specifically, future studies should investigate various live, immune cell populations by high parametric, multicolor immunophenotyping enabled sorting, and perform single-cell RNA sequencing (scRNA-seq) that would provide clues into which specific cell populations that contribute to the anti-tumor effect, and how the ARF alter the cellular metabolic changes translating into an increased expression of CCTF and CAM [3,62]. The gene discussed is CDKN2A; the disease is neoplasm.