This promiscuous interaction, in some cases, can block the activation of the apoptotic pathway [77], as in the case of TNF-α that induces apoptosis via TNF-R1 and TNF-R2 and can lead to tumor progression [40,78], and TRAIL also binds to decoy receptors (DcR1 and DcR2) that do not induce apoptosis [79]. This evidence concerns the gene TNF and neoplasm.