NME1 and Alzheimer disease: More recent proteomic analyses (2D gel electrophoresis followed by Matrix assisted lazer desorption/ionization mass-spectrometery (MALDI-MS) of tissues from different brain regions of patients with Alzheimer’s disease (AD) and Down’s Syndrome (DS) with AD-like neural pathology presented an important observation: NM23-H1 (also known as NDPK A) expression is substantially reduced in the frontal, parietal and occipital cortices.