CHRNA5 and chronic obstructive pulmonary disease: Our population haplotype analysis showed different blocks depending on the ancestral contribution; those with a Caucasian predominance had a higher risk (OR = 2.47) of suffering from COPD when a 93 kb haplotype was found in the CHRNA5-CHRNA3 genes (chromosome 15); however, in the group with a high AME contribution showing linkage disequilibrium, it did not have an associated haplotype.