Genome-wide CRISPR/Cas9 screening was applied in 786-O clear-cell renal cell carcinoma cells and OVCAR-8 ovarian carcinoma cells; several peroxisomal genes, such as peroxisomal biogenesis factor 10 (PEX10), peroxisomal biogenesis factor 3 (PEX3), alkyldihydroxyacetone phosphate synthase (AGPS) and fatty acyl-CoA reductase (FAR1), were identified to be required for ferroptosis [61]. This evidence concerns the gene PEX3 and ovarian carcinoma.