SPTBN2 and nasopharyngeal carcinoma, susceptibility to, 1: We hereby report two unrelated cases of non-progressive congenital ataxia (NPCA), with progressive cerebellar volume loss on MRI and the appearance of cortical hyperintensities over time, in carriers of novel de novo SPTBN2 mutations, c.764A > G (p.D255G) and c.193A > G (p.K65E).