NOS2 and diabetes mellitus: Studies show that inducible nitric oxide synthase/gamma-glutamylcysteine ligase (iNOS/GGCL) and dimethylaminohydrolase (DDAH) dysregulation may play a key role in oxidative stress mediated by high glucose levels, while heme oxygenase-1 inductors (HO-1), such as CAPE or its stronger derivatives, may be useful in diabetes and other oxidative stress-related conditions [65].