IRAK1 and COVID-19: More in detail, considering the effect of P. spinosa on HUVEC senescence without any additional triggers, although due to the current situation (i.e., COVID-19 emergency) our data were absolutely preliminary (one single experiment), the extract seemed to act as an anti-inflammatory agent, as shown by IL-6, IRAK-1, and miR-146a expression levels, evaluated in P2, P5, and P15 cells (Figure 7).