SARS-CoV-2 N inhibited the IFV-delNS1-induced induction of the IFN-β, IFN-λ1, IFN-λ2, ISRE, and IP-10 promoter activities mediated by RIG-I activation in A549 cells (Figure 4A).Similar results were observed in response to ZIKV (MR766) infection. The gene discussed is IFNL1; the disease is infection.