CAP/PAM treatment increases intracellular ROS, and DNA damage in Jurkat cells [107], which, in CAP treated osteosarcoma cells, leads to increase of p53/phospho-p53 expression, [107,110] and in HT29 and SW480 colon cancer cells to increase of p21 expression [111], resulting in cell cycle blockage and apoptosis. The gene discussed is TP53; the disease is colonic neoplasm.