FAS and melanoma: MAPK-induced apoptotic signalling was also noted in PAM treated TE354T basal cell carcinoma [104] and A875 melanoma cells, where CAP increased Sestrin2 expression and activated its downstream iNOS, Fas, and p38/MAPK signalling to induce apoptosis via Fas/TRAIL-mediated cell death receptor extrinsic pathway [89,105].