Although differences in IFNG and IL2 cytokine release were not significant after 24 h of co-culture, neuroblastoma cell encounter induced higher IFNG and IL2 release from human L1CAM-specific CAR T cells harboring the CD28 instead of 4-1BB co-stimulatory domain (Figure 3A), following the trend observed in murine CAR T cells. The gene discussed is CD28; the disease is neuroblastoma.