To avoid xenoreactivity of polyclonal murine T cells towards human neuroblastoma xenografts and to be able to follow T cell homing in vivo by bioluminescent imaging, CARs were introduced into CD8+ T cells derived from ChRLuc/OT-1/Rag−/− transgenic mice that exclusively express an OVA-specific tumor-unrelated TCR and are transgenic for Renilla luciferase (RLuc) [23]. The gene discussed is CD8A; the disease is neoplasm.