PLEKHA5 and neoplasm of cerebral hemisphere: Hyperactivation of PI3K/AKT pathway in response to stimuli from the intracranial microenvironment might be responsible for PDCD4 translocation from the nucleus to the cytoplasm and studies focused on PI3K/AKT signaling dynamics in relation to PLEKHA5 expression and PDCD4 intracellular localization in cerebral tumors compared to extracranial counterparts are warranted.