Hyperactivation of PI3K/AKT pathway in response to stimuli from the intracranial microenvironment might be responsible for PDCD4 translocation from the nucleus to the cytoplasm and studies focused on PI3K/AKT signaling dynamics in relation to PLEKHA5 expression and PDCD4 intracellular localization in cerebral tumors compared to extracranial counterparts are warranted. This evidence concerns the gene AKT1 and neoplasm of cerebral hemisphere.