Among the three TGFβ ligands, TGFB2 mutations which cause Loeys–Dietz syndrome 4 (LDS type 4) have been linked to aortic aneurysm and rupture and congenital heart defects, including valve malformations and septation abnormalities [8,30,31]. Here, TGFB1 is linked to aortic aneurysm.