CCNE1 and neoplasm: It was also observed with RNA levels that silencing of CDCA8 in HCC cells upregulated the expressions of apoptotic genes, such as CYR61 [28,29] and caspase-7 [30], and another tumor suppressor, KLF2 [31], which was paralleled with the suppression of important genes involved in cell growth (BGLAP [32] and ADAMTSL4 [33]) or cell division (SLBP [34] and cyclin E [35]).