Notably, as shown in Figure 5C (top network 1) and Figure 5D (top network 2), the antiproliferative effects were driven by the upregulation of tumor suppressive ATF3 [18] and PPP1R15A (GADD34) [19], whereas PCNA and BGLAP, key regulators of proliferation and invasion, were repressed. This evidence concerns the gene PPP1R15A and neoplasm.