TNNI3 and autoimmune disease: In Cohort 1, which consisted of samples from four biochemically divergent groups of patients, there was no correlation (Spearman’s rho = −0.03) between Ortho hs-cTnI and Abbott hs-cTnI in samples with CRP ≥ 90 mg/L (i.e., patients with an acute phase response), whereas a correlation was evident in samples collected in the presence of possible autoimmune diseases and poor renal function (Figure 1A).