For example, cabozantinib is a multi-kinase inhibitor of VEGFR-1, -2 and -3, KIT, TRKB, FLT-3, AXL, RET, MET and TIE -2, and regorafenib exhibits a broad spectrum of activity with inhibition of tyrosine kinases involved in tumor angiogenesis mechanisms (e.g., PDGFR, FGFRs 1–2, VEGFRs 1–3, TIE2), proliferation (RET, RAF, KIT), tumor microenvironment and metastasis processes (VEGFR2–3, PDGFR). The gene discussed is KDR; the disease is neoplasm.