For osimertinib, the latest generation of anti-EGFR TKIs, in the pivotal study FLAURA, 4% of patients in the osimertinib arm developed interstitial lung disease compared to 2% of patients in the standard EGFR-TKI arm (gefitinib or erlotinib) [46]. The gene discussed is EGFR; the disease is interstitial lung disease.