EGFR and non-small cell lung carcinoma: Finally, a clinical trial for afatinib in locally advanced or metastatic EGFR-mutated NSCLC revealed a significantly longer PFS with afatinib treatment than with gefitinib (mPFS, 11.0 months vs. 10.9 months; hazard ratio (HR), 0.73; 95% confidence interval (CI), 0.57–0.95; p = 0.017) [41].