LncRNA MEG3, a tumor suppressor reported to play important roles in various malignancies, has been demonstrated to regulate LATS2 by promoting the ubiquitination of EZH2 in gallbladder cancer [66], while lncRNA HOTAIR acts as an inducer of proteolysis by facilitating the ubiquitination of Ataxin-1 and Snurportin-1. The gene discussed is MEG3; the disease is neoplasm.