PVT1 and Familial prostate cancer: Previously, we have reported that PVT1 exon 9 is overexpressed in prostate cancer cell lines, especially in aggressively tumorigenic prostate cancer cell lines derived from men of African Ancestry [17] Furthermore, we have observed that PVT1 exon 9 is significantly overexpressed in prostate cancer tissue relative to both normal prostate tissue and benign prostatic hyperplasia [18].