Notably, pharmacologic inhibition HO-1 by ZnPP administration aggravated the dextran sulfate sodium-induced colitis, whereas the HO-1 inducer CoPP treatment ablated intestinal inflammation and fully protected CX3CR1 KO mice from azoxymethane and dextran sulfate sodium-induced colon carcinogenesis [67]. This evidence concerns the gene HMOX1 and colitis.