Existing literature on the same SNPs or SNPs in high LD to those analysed in this study showed no significant association with weight loss after 6 or 12 months in adults with overweight and obesity: rs6548238 of the TMEM18 gene, rs6265 of the BDNF gene, rs10913469, and rs543874 of the SEC16B gene [6,30]. This evidence concerns the gene TMEM18 and obesity due to melanocortin 4 receptor deficiency.