MTIF3 and diabetes mellitus: In the combined analysis of the Diabetes Prevention Program and the Look Action for Health in Diabetes (AHEAD) study (almost 6,000 participants) in which associations between 93 independent SNPs and weight loss were analysed, the SNP rs1885988 within the melanogenesis associated transcription factor 3 (MTIF3) gene was significantly associated with weight loss across all four years of follow-up [34].