More recently, Liu and co-workers (2020) [47] developed a computational pipeline, Integrative Modeling of Transcription Regulatory Interactions for Systematic Inference of Susceptibility in Cancer (inTRINSiC) (Table 1), to dissect the TF regulatory circuitry underlying the heterogeneity of GBM based on the integration of epigenomic, transcriptomic, protein interaction, and genetic perturbation. The gene discussed is TF; the disease is glioblastoma.