The dynamic changes in nuclear areas and chromosome numbers within the USP22-KO clones are in agreement with CIN, as ongoing chromosome mis-segregation events generate heterogeneous chromosome complements that confer different growth advantages and disadvantages, resulting in the selection of distinct cell populations harboring either losses or gains of chromosomes that are associated with smaller or larger nuclear areas, respectively. The gene discussed is USP22; the disease is cervical squamous intraepithelial neoplasia.