ITGA2B and autoimmune thrombocytopenic purpura: ITP is due to an autoimmune peripheral destruction of platelets by their recognition by autoantibodies (Figure 1), targeting different glycoproteins (GPs), mostly GPIIb/IIIa and GPIb/IX, that mediate antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) [6,7].