The most effective plant extracts, Humulus lupulus (HL), Hypericum perforatum (HP) and Curcuma amada (CA), were then tested for their effect on the JAK/STAT3 pathway and the marker of hyperproliferation in psoriasis, KRT17, that is regulated by the transcription factor NF-κB. The gene discussed is NFKB1; the disease is psoriasis.